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Цебопім порошок для ін'єкцій 1 г 1 флакон
D.S.
За карткою клієнта «D.S.» нараховуються бонусні бали (крім акційних товарів)
D.S.

Цебопім порошок для ін'єкцій 1 г 1 флакон

код товару: ЦБ000030704
Упаковка / 1 флакон
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Аптеки
від 124.30 грн
Упаковка
1

D.S.
За карткою клієнта «D.S.» нараховуються бонусні бали (крім акційних товарів)
D.S.
Доставка в: Львів >
Особливості застосування
Дорослим - дозволено
Дорослим дозволено
Дітям - з 1-го місяця за призначенням лікаря
Дітям з 1-го місяця за призначенням лікаря
Вагітним - за призначенням лікаря з урахуванням користь/ризик
Вагітним за призначенням лікаря з урахуванням користь/ризик
Алергікам - з обережністю
Алергікам з обережністю
Годуючим - заборонено
Годуючим заборонено
Діабетикам - з обережністю
Діабетикам з обережністю
Температура зберігання - не вище 30°C
Температура зберігання не вище 30°C
Водіям - не досліджувалось
Водіям не досліджувалось

Торгівельна назва Цебопім
Форма випуску порошок для ін'єкцій
Виробник Борщагівський ХФЗ
Країна власник ліцензії Україна
Умови відпуску Потрібен рецепт
Вид упаковки Упаковка
Кількість в упаковці 1 Упаковка(и)
Дивитися властивості номенклатури Дивитися інструкцію
Доставка в: Львів >
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Загальна характеристика: Загальна характеристика Цебопім порошок для ін'єкцій 1 г 1 флакон

  • Виробник: Цебопім порошок для ін'єкцій 1 г 1 флакон

    <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'></b><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> Публічне акціонерне товариство «Науково-виробничий центр «Борщагівський хіміко-фармацевтичний завод».</span></p>
  • Умови відпуску:

    <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'> </b><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>За рецептом.</span></p>
  • Лікарська форма:

    <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'> </b><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Порошок для розчину для ін’єкцій.</span><b style='mso-bidi-font-weight: normal' style='mso-bidi-font-weight: normal'></b></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Основні фізико-хімічні властивості:</i><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> порошок від білого до світло-жовтого кольору.</span></p>
  • Упаковка:

    <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'></b><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> Порошок для розчину для ін’єкцій по </span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>50</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>0 мг у флаконі. По 1 флакону в пачці.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Порошок для розчину для ін’єкцій по 1 г у флаконі. По 1 флакону в пачці; по 1 флакону в комплекті з розчинником (вода для ін’єкцій) по 5 мл або по 10 мл в ампулі в пачці з картонною перегородкою.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Порошок для розчину для ін’єкцій по 2 г у флаконі. По 1 флакону в пачці.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'></b><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> Порошок для раствора для инъекций по </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>500 м</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>г во флаконе. По 1 флакону</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>в пачке;</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Порошок для раствора для инъекций по </span><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> во флаконе. По 1 флакону</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>в пачке; по 1 флакону в комплекте с растворителем </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>(</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>вода для инъекций) по 5 мл или </span><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>по </span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'>10 мл в ампуле в пачке </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>с </span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>картонной перегородкой.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Порошок для раствора для инъекций по </span><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> во флаконе. По 1 флакону</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>в пачке</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Категория отпуска. </b><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>По рецепту.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Производитель.</b><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>П</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>убличное акционерное общество «Научно-производственный центр </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU;mso-bidi-font-weight:bold'>«</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU;mso-bidi-font-weight:bold' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU;mso-bidi-font-weight:bold'>Борщаговский химико-фармацевтический завод</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU;mso-bidi-font-weight:bold'>»</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU;mso-bidi-font-weight:bold' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU;mso-bidi-font-weight:bold'>.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Местонахождение</b><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'> производителя и адрес места осуществления его деятельности. </b><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>Украина, 03134, г. Киев, ул. Мира, 17.</span><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'></b></p>
  • Фармацевтична група:

    <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'></b><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'> Антибактеріальні засоби для системного застосування. Інші бета-лактамні антибіотики. Цефалоспорини IV покоління. Код ATХ J01D E01.</span></p>
  • Код АТХ:

Протипоказання: Протипоказання Цебопім порошок для ін'єкцій 1 г 1 флакон

  • <p><span lang='UK' style='font-size:12.0pt
  • font-family:Symbol
  • mso-fareast-font-family: Symbol
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  • font-family:"Times New Roman"
  • mso-fareast-font-family:"Times New Roman"
  • mso-ansi-language:UK
  • mso-fareast-language:RU'>Гіперчутливість до цефепіму або L-аргініну
  • </span></p> <p><span lang='UK' style='font-size:12.0pt
  • font-family:Symbol
  • mso-fareast-font-family: Symbol
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  • mso-fareast-font-family:"Times New Roman"
  • mso-ansi-language:UK
  • mso-fareast-language:RU'>гіперчутливість до антибіотиків цефалоспоринового ряду, пеніцилінів або інших бета-лактамних антибіотиків.</span></p>

Застосування: Застосування Цебопім порошок для ін'єкцій 1 г 1 флакон

<p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Перед застосуванням препарату слід зробити шкірну пробу на переносимість.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Дози та шлях введення можуть варіювати залежно від чутливості, локалізації та типу мікроорганізмів, ступеня тяжкості інфекції, а також віку та функціонального стану організму пацієнта. Зазвичай дорослим препарат слід вводити по 1 г внутрішньовенно/внутрішньом’язово через кожні 12 годин. Курс лікування становить 7-10 днів. Тяжкі інфекції можуть потребувати тривалішого лікування.</span></p> <p><span lang='UK' style='font-size:12.0pt;line-height: 150%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>Рекомендації щодо дозування препарату Цебопім для дорослих наведені у таблиці 1. </span><span style='font-size:12.0pt;line-height:150%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;line-height:150%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>Таблиця 1.</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Інфекції сечовивідних шляхів (легкого та середнього ступеня тяжкості)</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>500 мг-1 г внутрішньовенно або внутрішньом’язово</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>кожні 12 годин</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Інші інфекції (легкого та середнього ступеня тяжкості)</span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> внутрішньовенно або внутрішньом’язово</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>кожні 12 годин</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Тяжкі інфекції</span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> внутрішньовенно </span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>кожні 12 годин</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Дуже тяжкі та загрожуючі життю інфекції</span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> внутрішньовенно</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>кожні 8 годин</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Пацієнтам віком від 65 років з нормальною функцією нирок дози препарату не потребують корекції.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Профілактика можливого інфікування при проведенні хірургічних операцій</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>. 2 г препарату вводити внутрішньовенно краплинно впродовж 30 хвилин за 1 годину до початку хірургічної операції. Після закінчення введення додатково вводити 500 мг метронідазолу внутрішньовенно. Розчин метронідазолу не слід вводити одночасно з препаратом Цебопім. У випадку одночасного застосування кожен антибіотик вводити в окремих системах. При застосуванні одї системи для двох препаратів перед інфузією метронідазолу систему слід промити.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Під час тривалих (понад 12 годин) хірургічних операцій через 12 годин після першої дози рекомендується повторне введення такої ж дози препарату Цебопім з наступним введенням метронідазолу.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Діти віком від 1 до 2 місяців. </i><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Застосовувати тільки за життєвими показаннями. водити у дозі 30 мг/кг маси тіла кожні 12 або 8 годин. Стан дітей з масою тіла до 40 кг, які отримують лікування Цебопімом, потрібно постійно контролювати.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Діти віком від 2 місяців.</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'> Максимальна доза для дітей не повинна перевищувати рекомендовану для дорослих. Дітям з масою тіла до 40 кг рекомендована доза становить 50 мг/кг кожні 12 годин (пацієнтам на фебрильну нейтропенію та бактеріальний менінгіт – кожні 8 годин). Тривалість терапії становить 7-10 днів, тяжкі інфекції можуть вимагати тривалішого лікування.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Дітям з масою тіла 40 кг і більше Цебопім призначати, як і дорослим.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Порушення функції нирок.</i><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'> У пацієнтів із порушеною функцією нирок (кліренс креатиніну менше 30 мл/хв) необхідно коригувати режим введення препарату. При цьому початкова доза Цебопіму аналогічна дозі для пацієнтів із незміненою функцією нирок. Рекомендовані підтримуючі дози препарату Цебопім наведені у таблиці 2.</span></p> <p><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>Таблиця 2.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Кл</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ренс креатин</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>н</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у (мл/хв)</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>Рекомендован</span><span lang='UK' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'> п</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>ідтримуючі</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> доз</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>и</span></p> <p><span lang='UK' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>Інфекції сечовивідних шляхів</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> (легко</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>го</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>та</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> с</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>е</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>редн</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ього</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> ст</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>пен</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>я</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>тяжкості)</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>Інші і</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>нфекц</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ії</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> (легко</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>го</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>та</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> средн</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ього</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> ст</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>пен</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>я</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>тяжкості)</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>Тяжкі</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ін</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>фекц</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ії</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>Дуже</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>тяжкі та загрожуючі життю інфекції</span><span style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>> 50</span><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>12 годин</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> кожні 12 годин</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>12 годин</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> кожні 8 годин</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Звичайне </span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>доз</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ування</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> адекват</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>н</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>е тяж</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>кості</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>нфекц</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ії</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>, корекц</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>я доз</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>и</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> не </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>потрібна</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>30-50</span><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>24 години</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>24 години</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>24 години</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>12 годин</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>11-29</span><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>24 години</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>24 години</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>24 години</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>24 години</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>≤ 10</span><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>250 мг кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>24 години</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>250 мг кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>24 години</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>24 години</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> кожні</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>24 години</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>гемодіаліз</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг кожні 24 години</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг кожні 24 години</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг кожні 24 години</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг кожні 24 години</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Кліренс креатиніну визначають за формулою:</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Чоловіки: </span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Жінки:</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>При гемод</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ал</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>з</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> за 3 </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>години</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> з орган</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>зм</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у ви</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>даля</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>є</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>т</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ь</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ся приблизно 68</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>від</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> введено</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ї</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> доз</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>и</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> препарат</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>. П</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>сл</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>я</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> к</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>о</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ж</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>н</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ого сеанс</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> гемод</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ал</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>з</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> необх</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>д</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>но</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> вводит</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>и</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> повторну дозу,</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> яка аналогічна</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>початковій</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>. При </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>безперервному</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> амбулаторном</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> пер</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>и</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>тонеальном</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> д</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ал</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>з</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> препарат можн</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>а</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>застосовувати</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> в нормальн</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>и</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>х рекомендован</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>и</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>х дозах за</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>лежно</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>від</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>тяжкості</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>нфекц</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ії</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>, </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>з</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>нтервалом м</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ж введен</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>н</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ями разово</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ї</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> доз</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>и</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> 48 </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>годин</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>При по</span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>рушен</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>ні</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'> функц</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>ії</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>нирок</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> у д</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>тей рекоменд</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>овано</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>з</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>нижен</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ня</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> доз</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>и</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>або</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>подовження</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>нтервал</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> м</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ж введен</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>н</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ями, </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>я</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>к </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>в</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>казано в таблиц</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>2.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Розрахунок показників кліренсу креатиніну у дітей:</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>або</span></p> <p><i land='' style=''>ведення препарату.</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'> </span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Цебопім вводити внутрішньовенно або глибоко внутрішньом’язово у велику м’язову масу (наприклад, у верхній зовнішній квадрант сідничного м’яза). </span></p> <p><i land='' style=''>нутрішньовенне введення.</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'> Даний шлях введення переважно застосовується пацієнтам із тяжкими, загрозливими для життя інфекціями.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>При внутрішньовенному способі введення Цебопім розчинити в 5 або 10 мл стерильної води для ін’єкцій, 5 % розчині глюкози або 0,9 % розчині натрію хлориду, як зазначено в таблиці 3. Готовий розчин вводити повільно струминно протягом 3-5 хвилин або крапельно через систему для внутрішньовенного введення.</span></p> <p><i land='' style=''>нутрішньом</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>’язове введення. Цебопім розчинити у стерильній воді для ін’єкцій, 0,9 % розчині натрію хлориду, 5 % розчині глюкози для ін’єкцій, бактеріостатичній воді для ін’єкцій з парабеном або бензиловим спиртом, 0,5 % або 1 % розчині лідокаїну гідрохлориду в концентраціях, які вказані в таблиці 3. </span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>При застосуванні лідокаїну в якості розчинника перед введенням слід зробити шкірну пробу на його переносимість.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Як і інші лікарські засоби, що застосовуються парентерально, готові розчини препарату перед </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>в</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>веденням необхідно перевіряти на відсутність механічних включень. </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>Таблиця 3.</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Об</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>’</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>єм розчину для розведення (мл)</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Приблизний об</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>’</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>єм </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>отриманого</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> розчину (мл)</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Приблизна концентрація цефепіму (мг/мл)</span><span style='font-size: 10.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 10.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>нутр</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ішньовенне</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> введен</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ня</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>500 мг/флакон</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>5</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>5,7</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>90</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>1 г/флакон</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>10</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>11,4</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>90</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>2 г/флакон</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>10</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>12,8</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>160</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>нутр</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ішньом</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>’</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>язове</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> введен</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ня</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>500 мг/флакон</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>1,5</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>2,2</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>230</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>1 г/флакон</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>3,0</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>4,4</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>230</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Не змішувати в одній ємності з іншими препаратами. Застосовувати розчинники, перелічені у розділі « та дози»</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>.</span></p>

Протипоказання: Протипоказання Цебопім порошок для ін'єкцій 1 г 1 флакон

  • <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Дорослі.</i></p> <p><span lang='UK' style='font-size:12.0pt
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  • mso-fareast-language:RU'>Інфекції, спричинені чутливою до препарату мікрофлорою:</span></p> <p><span lang='UK' style='font-size:12.0pt
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  • mso-fareast-font-family:"Times New Roman"
  • mso-ansi-language:UK
  • mso-fareast-language:RU'>дихальних шляхів, у тому числі пневмонія, бронхіт
  • </span></p> <p><span lang='UK' style='font-size:12.0pt
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  • mso-ansi-language:UK
  • mso-fareast-language:RU'>шкіри та підшкірної клітковини
  • </span></p> <p><span lang='UK' style='font-size:12.0pt
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  • mso-fareast-language:RU'>інтраабдомінальні інфекції, у тому числі перитоніт та інфекції жовчовивідних шляхів
  • </span></p> <p><span lang='UK' style='font-size:12.0pt
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  • mso-fareast-font-family:"Times New Roman"
  • mso-ansi-language:UK
  • mso-fareast-language:RU'>інфекції сечовивідних шляхів, у тому числі пієлонефрит
  • </span></p> <p><span lang='UK' style='font-size:12.0pt
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  • mso-fareast-font-family:"Times New Roman"
  • mso-ansi-language:UK
  • mso-fareast-language:RU'>гінекологічні
  • </span></p> <p><span lang='UK' style='font-size:12.0pt
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  • mso-fareast-font-family:"Times New Roman"
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  • mso-fareast-language:RU'>септицемія.</span></p> <p><span lang='UK' style='font-size:12.0pt
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  • mso-fareast-language:RU'>Емпірична терапія хворих із нейтропенічною гарячкою.</span></p> <p><span lang='UK' style='font-size:12.0pt
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  • mso-fareast-language:RU'>Профілактика післяопераційних ускладнень в інтраабдомінальній хірургії.</span></p>

Побічна дія: Побічна дія Цебопім порошок для ін'єкцій 1 г 1 флакон

<p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Побічні реакції спостерігаються рідко.</span></p> <p><i land='' style=''>Імунна система: </i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:UK'>реакції гіперчутливості, включаючи анафілаксію, анафілактичний шок, ангіоневротичний набряк.</span></p> <p><i land='' style=''>Шкіра та підшкірна клітковина: </i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:UK'>шкірні висипання, свербіж, кропив’янка.</span></p> <p><i land='' style=''>Травна система</i><i land='' style=''>: </i><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:UK' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:UK'>нудота, блювання, кандидоз ротової порожнини, діарея, коліт, запор, біль у животі, диспепсія, зміна відчуття смаку.</span></p> <p><i land='' style=''>Гепатобіліарна система: </i><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK'>гепатит, холестатична жовтяниця.</span></p> <p><i land='' style=''>Нервова система: </i><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK'>запаморочення, головний біль, неспокій, безсоння, парестезії, сплутаність/втрата свідомості, судоми/епілептоформні напади, міоклонія, енцефалопатія, галюцинації, ступор, кома.</span></p> <p><i land='' style=''>Загальні розлади та зміни у місці введення: </i><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:UK'>підвищення температури тіла, пітливість, біль у грудях/спині, астенія, зміни у місці введення, включаючи запалення, флебіт, біль.</span></p> <p><i land='' style=''>Інфекції:</i><i land='' style=''> </i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:UK'>кандидоз, вагініт, генітальний свербіж, псевдомембранозний коліт, інші суперінфекції.</span></p> <p><i land='' style=''>Дихальна система: </i><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK'>розлади дихання, кашель, біль у горлі, задишка.</span></p> <p><i land='' style=''>Серцево-судинна система: </i><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK'>тахікардія, вазодилатація, біль у ділянці серця.</span></p> <p><i land='' style=''>Сечовидільна система: </i><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK'>ниркова недостатність.</span></p> <p><i land='' style=''>Кров та лімфатична система: </i><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK'>анемія, еозинофілія, транзиторна лейкопенія, нейтропенія, агранулоцитоз, тромбоцитопенія.</span></p> <p><i land='' style=''>Лабораторні показники: </i><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK'>збільшення рівня аланінамінотрансферази, аспарататамінотрансферази, лужної фосфатази, загального білірубіну в плазмі крові, збільшення протромбінового часу або парціального тромболастинового часу (ПТТ) і позитивний результат тесту Кумбса без гемолізу, тимчасове збільшення азоту сечовини крові та/або креатиніну сироватки</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: UK'> крові</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK'>, хибнопозитивна реакція на глюкозу в сечі.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:UK'>Крім вищезазначених побічних реакцій можливі побічні реакції, характерні для антибіотиків групи цефалоспоринів: синдром Стівенса-Джонсона, мультиформна еритема, токсичний епідермальний некроліз, токсична нефропатія, апластична анемія, гемолітична анемія, кровотечі, порушення функції печінки, холестаз, панцитопенія.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Термін придатності. </b><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>3 роки.</span></p>

Передозування: Передозування Цебопім порошок для ін'єкцій 1 г 1 флакон

<p><i land='' style=''>Симптоми: </i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>у разі значного перевищення рекомендованих доз, особливо у </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>пацієнтів</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> з порушеною функцією нирок, посилюються прояви побічної дії. Симптоми передозування включають енцефалопатію, що супроводжується галюцинаціями, порушенням свідомості, ступором, комою, міоклою, епілептоформними нападами, нейромКјязовою збудливістю.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Лікування.</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> Слід припинити введення препарату, провести симптоматичну терапію. Застосування гемодіалізу пришвидшує виведення цефепіму з організму; перитонеальний діаліз малоефективний. Тяжкі алергічні реакції негайного типу потребують застосування адреналіну та інших форм інтенсивної терапії.</span></p>

Застосування в період вагітності: Застосування в період вагітності Цебопім порошок для ін'єкцій 1 г 1 флакон

<p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Дослідження на тваринах продемонстрували відсутність впливу на репродуктивну функцію і відсутність будь-якого шкідливого впливу на плід.</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>Однак </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>адекватних і добре контрольованих досліджень у вагітних жінок не проводилося, тому Цебопім у період вагітності можна призначати тільки тоді, коли очікувана користь для матері перевищує потенційний ризик для плода.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Цефепім проникає у грудне молоко в дуже невеликій кількості, тому під час лікування Цебопімом годування груддю слід припинити.</span></p>

Діти: Діти Цебопім порошок для ін'єкцій 1 г 1 флакон

<p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>У дітей у віці від 2 місяців до 11 років після одноразової внутрішньовенної ін’єкції загальний кліренс та об’єм розподілу в стаціонарному стані становить 3,3 (± 1,0) мл/хв/кг та 0,3 (± 0,1) л/кг, відповідно. </span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Близько 60,4 (± 30,4) % від дози цефепіму, яку ввели, виділяється у незміненому вигляді із сечею, нирковий кліренс дорівнює 2,0 (± 1,1) мл/хв/кг. Після внутрішньом’язового введення максимальна концентрація цефепіму в плазмі крові в рівноважному стані становить у середньому 68 мкг/мл через 0,75 години. Через 8 годин після внутрішньом’язового введення концентрація цефепіму в плазмі крові становить 6 мкг/мл. Абсолютна біодоступність після внутрішньом’язової ін’єкції цефепіму становить у середньому 82 %. ік та стать пацієнтів не впливають на кліренс препарату.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Концентрац</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>ії</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'> препарат</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>у</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'> в спин</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>н</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>омоз</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>к</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>ов</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>і</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>й </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>рідині</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> (СМ</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Р</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>)</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> та</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> в плазм</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>і</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> кров</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>і</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> у д</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>і</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>тей</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>,</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>хворих</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>на </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>бактер</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>і</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>альн</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>ий</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> мен</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>і</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>нг</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>і</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>т</i></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Час </span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>п</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>сл</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>я</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> введен</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>н</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>я (</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>г</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>)</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Концентрац</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>я </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> плазм</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>крові </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>(мкг/мл)*</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Концентрац</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>я </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> СМ</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>Р</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> (мкг/мл)*</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>ідношення</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> концентрац</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>ії</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> СМ</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>Р</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>/плазм</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> кров</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> *</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>0,5</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>67,7</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>51,2</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>5,7</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>0,14</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>0,12</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>0,14</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>1</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>44,1</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>7,8</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>4,3</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>1,5</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>0,10</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>0,04</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>2</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>23,9</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>12,9</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>3,6</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>2,0</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>0,17</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>0,09</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>4</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>11,7</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>15,7</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>4,2</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>1,1</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>0,87</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>0,56</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>8</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>4,9</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>5,9</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>3,3</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>2,8</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>1,02</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>±</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>0,64</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>* в</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ік</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>від</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> 3,1 м</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>сяц</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>я</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> до 12 </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>років</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>зі</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> стандартн</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>и</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>м </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>відхиленням у</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> в</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>іці</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> ±</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>3 </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>роки</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Доза препарат</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>у</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> 50 мг/кг мас</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>и</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>тіла</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> при внутр</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ішньовенному</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> введен</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ні</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>впродовж</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> 5-20 </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>хвилин</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> к</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>о</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ж</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ні</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> 8</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> годин</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>. Концентрац</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>я </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>у</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> плазм</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> кров</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>та</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> СМ</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>Р</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>визначалась у</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> к</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>нц</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>і</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> введен</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>н</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>я на 2 </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>або</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> 3 день л</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ікування</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> препаратом.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:UK;mso-fareast-language: RU'>· </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>Пневмонія;</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:UK;mso-fareast-language: RU'>· </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>інфекції сечовивідних шляхів, у тому числі пієлонефрит;</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:UK;mso-fareast-language: RU'>· </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>інфекції шкіри та підшкірної клітковини;</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:UK;mso-fareast-language: RU'>· </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>септицемія;</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:UK;mso-fareast-language: RU'>· </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>емпірична терапія хворих із нейтропенічною гарячкою;</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family: Symbol;mso-bidi-font-family:Symbol;mso-ansi-language:UK;mso-fareast-language: RU'>· </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>бактеріальний менінгіт.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Препарат застосовувати дітям віком від 1 місяця.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>При застосуванні лідокаїну як розчинника слід врахувати інформацію з безпеки лідокаїну.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>У детей в возрасте от 2 месяцев до 11 лет после однократной внутривенной инъекции общий клиренс и объем распределения в стационарном состоянии составляют 3,3 (± 1,0) мл/мин/кг и 0,3</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>(± 0,1) л/кг соответственно.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Около 60,4 (± 30,4) % от введенной дозы цефепима выделяется в неизмененном виде с мочой, почечный клиренс равен 2,0 (± 1,1) мл/мин/кг. После внутримышечного введения максимальная концентрация цефепима в плазме крови в равновесном состоянии составляет в среднем 68 мкг/мл через 0,75 часа. Через 8 часов после внутримышечного введения концентрация цефепима в плазме крови составляет 6 мкг/мл. Абсолютная биодоступность после внутримышечной инъекции цефепима составляет в среднем 82</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>%. озраст и пол пациентов не влияют на клиренс препарата.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Концентрации препарата в спинномозговой жидкости (СМЖ) и в плазме крови у детей</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>,</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'> больных бактериальным менингитом</i></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>ремя после</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'></span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>введения (ч)</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'></span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Концентрация в</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>плазме </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>крови </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>(мкг/мл)*</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Концентрация в СМЖ (мкг/мл)*</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Отношение концентрации в СМЖ/плазме крови *</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>0,5</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>67,7 ± 51,2</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>5,7 ± 0,14</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>0,12 ± 0,14</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>1</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>44,1 ± 7,8</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>4,3 ± 1,5</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>0,10 ± 0,04</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>2</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>23,9 ± 12,9</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>3,6 ± 2,0</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>0,17 ± 0,09</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>4</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>11,7 ± 15,7</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>4,2 ± 1,1</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>0,87 ± 0,56</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>8</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>4,9 ± 5,9</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>3,3 ± 2,8</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>1,02 ± 0,64</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>* возраст от 3,1 месяца до 12 лет со стандартным отклонением в возрасте ± 3 года.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Доза препарата 50 мг/кг массы тела при внутривенном введении на протяжении 5-20 минут каждые 8 часов. Концентрация в плазме крови и СМЖ определялась в конце введения на 2 или 3 день лечения препаратом.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Клинические характеристики. </b></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Показания.</b></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>зрослые.</i></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Инфекции, вызванные чувствительной к препарату микрофлорой:</span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>дыхательных путей, в том числе пневмония, бронхит;</span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>кожи и подкожной клетчатки;</span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>интраабдоминальные инфекции, в том числе перитонит и инфекции желчевыводящих путей;</span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>инфекции мочевыводящих путей, в том числе пиелонефрит;</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>гинекологические;</span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>септицемия.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Эмпирическая терапия больных с нейтропенической лихорадкой.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Профилактика послеоперационных осложнений в интраабдоминальной хирургии.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>Пневмония;</span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>инфекции мочевыводящих путей, в том числе пиелонефрит;</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>инфекции кожи и подкожной клетчатки;</span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>септицемия;</span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>эмпирическая терапия больных с нейтропенической лихорадкой;</span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>бактериальный менингит.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Противопоказания. </b><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>Гиперчувствительность к цефепиму или L-аргинину;</span></p> <p><span style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU' style='font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol; mso-bidi-font-family:Symbol;mso-fareast-language:RU'>· </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>гиперчувствительность к антибиотикам цефалоспоринового ряда, пенициллинам или другим </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>бета</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>-лактамным антибиотикам.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>заимодействие с другими лекарственными средствами и другие виды взаимодействий.</b><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Раствор </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ц</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>е</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>фе</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>пим</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>а</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> совместим со следующими парентеральными растворами: 0,9</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% раствором натрия хлорида</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>,</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> 5</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% или 10</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% растворами глюкозы</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>,</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><metricconverter productid='6 ГЊ' style=''>6 М</metricconverter><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'> раствором натрия лактата для инъекций, раствором Рингера лактата с 5</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% раствором декстрозы для инъекций.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Учитывая потенциальную нефротоксичность и ототоксичность аминогликозидных антибиотиков, высокие дозы данных препаратов применяют одновременно с </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>ц</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>е</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>фе</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>пимом под контролем функции почек. </span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>П</span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'>рименение цефалоспоринов с диуретиками (например, фуросемид) приводит к повышению нефротоксичности первых.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Чтобы избежать возможного лекарственного взаимодействия с другими препаратами, раствор </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>ц</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>е</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>фе</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>пим</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>а</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> (как и большинств</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>о</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> других бета-лактамных антибиотиков) не вводят одновременно с растворами метронидазола, ванкомицина, гентамицина, тобрамицина сульфата и нетилмицина сульфата. случае назначения препарата Цебопим с указанными препаратами вводят каждый антибиотик отдельно.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Сопутствующее лечение бактериостатическими антибиотиками может влиять на действие бета-лактамных антибиотиков.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>лияние на результаты лабораторных тестов.</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'></i></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Применение цефепима может привести к ложноположительной реакции на глюкозу в моче при использовании реактива Бенедикта. Рекомендуется использовать тесты на глюкозу, основанные на ферментной реакции окисления глюкозы.</span><b style='mso-bidi-font-weight: normal' style='mso-bidi-font-weight: normal'></b></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Особенности применения.</b><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Гиперчувствительность</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Перед применением препарата необходимо выяснить, отмечались ли ранее у пациента реакции гиперчувствительности немедленного типа на цефепим, цефалоспорины, </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>пенициллины или другие бета-лактамные антибиотики. </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Цефепим следует применять с осторожностью пациентам с астмой или аллергическим диатезом. Состояние пациента необходимо тщательно контролировать во время первого введения. Если возникает аллергическая реакция, лечение следует немедленно прекратить.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Антибиотики следует назначать с осторожностью всем </span><span lang='UK' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>пациентам</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> с любыми формами аллергии, особенно на лекарственные препараты. При появлении аллергической реакции применение препарата следует прекратить. Серьезные реакции гиперчувствительности немедленного типа могут требовать применения адреналина и других форм терапии. У пациентов с высоким риском тяжелых инфекций (например, у пациентов, которые имели в анамнезе трансплантацию костного мозга при сниженной его активности, которая возникает на фоне злокачественной гем</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>атологи</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>ческой патологии с тяжелой прогрессирующей нейтропенией) монотерапия может быть недостаточной, поэтому показана комплексная антимикробная терапия.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Антибактериальная активность цефепима</i><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Маловероятно, что назначение цефепима при отсутствии доказанной или подозреваемой бактериальной инфекции или </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>его </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>профилактическое применение будет полезным, но это может увеличить риск появления бактерий, невосприимчивых к этому </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>препарату</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>. </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Длительное применение цефепима (как и других антибиотиков) может приводить к развитию суперинфекции. Необходимо проводить повторную проверку состояния пациента. случае развития суперинфекции необходимо начать адекватные меры лечения.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Почечная недостаточность</i></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Пациентам с нарушением функции почек (с клиренсом креатинина < 50 мл/мин) дозу препарата следует скорректировать, чтобы компенсировать </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>за</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>медлен</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ие</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> скорост</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>и</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> почечного выведения. Поскольку высокие концентрации антибиотика в сыворотке крови могут иметь место при обычных дозах у пациентов с почечной недостаточностью или другими состояниями, которые могут ухудшить функции почек, при введении цефепима таким пациентам поддерживающая доза должна быть снижена. </span><span lang='UK' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>П</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>ри определении следующей дозы </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>препарата</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> следует учитывать </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>с</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>тепень нарушения функции почек, тяжесть инфекции и восприимчивости к </span><span lang='UK' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>микро</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>организмам, которые вызвали инфекцию.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>о время постмаркетингового исследования были зарегистрированы следующие серьезные побочные </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>реакции</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>: оборотная энцефалопатия (нарушение сознания, включая спутанность, галлюцинации, ступор и кома), миоклонус, судороги (в т.ч. эпилептический статус) и/или почечная недостаточность. Большинство случаев наблюдались у пациентов с почечной недостаточностью, получавших дозы цефепима, превышающие рекомендуемые.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> большинстве случаев симптомы нефротоксичности были оборотные и исчезали после отмены цефепима и/или после гемодиализа.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Clostridium difficile ассоциированная диарея</i></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Сообщалось о антибиотико-ассоциированной диарее и антибиотико-ассоциированном колите, включая псевдомембранозный колит и диарею, связанную с Clostridium difficile, в связи с применением почти всех антибиотиков, включая цефепим, что может варьировать от легкой диареи до колита</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> с летальным исходом</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>. Поэтому важно учитывать этот диагноз у пациентов, у которых развивается серьезная диарея во время или после применения цефепима. Если подозревается или подтверждается антибиотико-ассоциированная диарея или антибиотико-ассоциированный колит, следует прекратить лечение антибактериальными средствами, включая цефепим, и немедленно начать адекватные терапевтические мероприятия. Препараты, подавляющие перистальтику, в данной ситуации противопоказаны.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Пациенты пожилого возраста</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'></i></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Известно, что цефепим в значительной степени выделяется почками, и риск токсических реакций на этот препарат может быть выше у пациентов с почечной недостаточностью. Поскольку пожилые пациенты более склонны к снижению функции почек, следует осторожно подходить к выбору дозы, а функцию почек следует контролировать. </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>С</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>ерологическое тестирование</i></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Цефалоспорины склонны абсорбироваться на поверхности эритроцитов и вступать в реакцию с антителами, направленными против препаратов, результатом </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>че</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>го является положительный тест Кумбса. У пациентов, которые принимали цефепим 2 раза в сутки, описано положительный тест Кумбса при отсутствии признаков гемолиза. </span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>При проведении анализа мочи на глюкозури</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>ю</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'> возможен ложно-положительный результат. По этой причине определение глюкозы в моче следует проводить глюкозооксидазн</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ыми</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> методами в период лечения</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> препаратом</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Необходимо осуществлять контроль протромбинового времени.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>При применении лидокаина в качестве растворителя следует учесть информацию по безопасности лидокаина.</span><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Было доказано, что L-аргинин изменяет метаболизм глюкозы и одновременно увеличивает уровень калия в сыворотке крови при применении доз, которые в 33 раза превышают максимальную рекомендованную дозу цефепима. Эффекты при более низких дозах на данный момент неизвестны.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Применение в период беременности или кормления грудью.</i></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Исследования на животных продемонстрировали отсутствие воздействия на репродуктивную функцию и отсутствие какого-либо вредного воздействия на плод.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> Однако а</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>декватных и хорошо контролируемых исследований у беременных женщин не проводилось, поэтому Цебопим в период беременности можно назначать только тогда, когда ожидаемая польза для матери превышает потенциальный риск для плода.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Цефепим </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>проникает</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> в грудное молоко в очень небольшом количестве, поэтому во время лечения Цебопимом кормление грудью следует прекратить.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Способность влиять на скорость реакции при управлении автотранспортом или другими механизмами.</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Не изучалась. случае возникновения головокружения, галлюцинаций, спутанности сознания или других побочных эффектов со стороны нервной системы, которые могут влиять на скорость реакци</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>и</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>, следует воздерживаться от управления автомобилем или другими механизмами.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Способ применения и дозы.</b><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Перед применением препарата следует сделать </span><span lang='UK' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>кожную </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>пробу на переносимость.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Дозы и путь введения </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>могут варьировать</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> в зависимости от чувствительности, локализации и типа микроорганизмов</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>,</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> степени тяжести инфекции, а также возраста и функционального состояния организма пациента. Обычно взрослым препарат </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>следует </span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>ввод</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ить</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>по 1 г внутривенно/внутримышечно через каждые 12 часов. Курс</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> лечения составляет 7-10 дней. Тяжелые инфекции могут потребовать более длительного лечения.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>Рекомендации относительно дозирования препарата Цебопим для взрослых приведены в таблице</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> 1</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>.</span></p> <p><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>Таблица 1</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Инфекции мочевыводящих путей (легкой и средней степени тяжести</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>)</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>500 мг-1 г </span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>внутривенно</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> или </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>внутримышечно</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>каждые 12 часов</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Другие инфекции (легкой и средней степени тяжести</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>)</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>внутривенно</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> или </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>внутримышечно</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>каждые 12 часов</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Тяжелые инфекции</span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>внутривенно</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>каждые 12 часов</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Очень тяжелые и угрожающие жизни инфекции</span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>внутривенно</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>каждые 8 часов</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Пациентам </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>старше</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> 65 лет с нормальной функцией почек дозы препарата не требуют коррекции. </span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Профилактика возможного инфицирования при проведении хирургических операций</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>. 2 г препарата ввод</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ить</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> внутривенно капельно в течение 30 минут за 1 час до начала хирургической операции. После окончания введения дополнительно ввод</span><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>ить</span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'> 500 мг метронидазола внутривенно. Раствор метронидазола не следует вводить одновременно с препаратом Цебопим. случае одновременного применения каждый антибиотик ввод</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>ить</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> в отдельных системах. При использовании одной системы для двух препаратов – перед инфузией метронидазола систему следует промыть.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>о время длительных (более 12 часов) хирургических операций через 12 часов после первой дозы рекомендуется повторное введение т</span><span lang='UK' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>ак</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>ой же дозы препарата Цебопим с последующим введением метронидазола.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Дети возрастом от 1 до 2 месяцев. </i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>Применя</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ть</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> только по жизненным показаниям. вод</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ить</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> в дозе 30 мг/кг массы тела каждые 12 или 8 часов. Состояние детей с массой тела до 40 кг, которые получают лечение Цебопимом, нужно постоянно контролировать.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Дети возрастом от 2 месяцев.</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> Максимальная доза </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>для детей </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>не должна превышать рекомендуемую дозу для взрослых. Для детей с массой тела до 40 кг рекомендованная доза составляет 50 мг/кг каждые</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>12</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>часов (пациентам с фебрильной нейтропенией и бактериальным менингитом – каждые 8 часов). Продолжительность терапии составляет 7-10 дней, тяжелые инфекции могут требовать более длительного лечения.</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Детям с массой тела 40 кг и больше Цебопим назнача</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>ть</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>, как </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>и </span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>взрослым.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Нарушения функции почек.</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> У пациентов с нарушенной функцией почек (клиренс креатинина менее </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>30 мл/мин) необходим</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>о</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> корр</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>игировать</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> режим введения препарата. При этом </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>начальная </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>доза Цебопима </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>аналогична дозе для пациентов с неизмененной функцией почек</span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>. Рекомендованные поддерживающие дозы препарата Цебопим приведены в таблице 2.</span></p> <p><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'>Таблица 2</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Клиренс креатинина</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'> (мл/мин)</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>Рекомендованные поддерживающие дозы</span></p> <p><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>Инфекции мочевыделительных путей (легкой и средней степени тяжести</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>)</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>Другие инфекции (легкой и средней степени тяжести</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>)</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>Тяжелые инфекции</span></p> <p><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>Очень тяжелые и угрожающие жизни инфекции</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>> 50</span><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг каждые</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>12 часов</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> каждые</span><span lang='UK' style='font-size:10.0pt;font-family:Verdana;mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>12 часов</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> каждые 12 часов</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> каждые 8 часов</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Обычное дозирование адекватное тяжести инфекции, коррекция дозы не требуется</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>30-50</span><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг каждые 24 часа</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> каждые 24 часа</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> каждые 24 часа </span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> каждые 12 часов</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>11-29</span><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг каждые 24 часа</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг каждые 24 часа</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> каждые 24 часа</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> каждые 24 часа</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>≤ 10</span><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>250 мг каждые 24 часа</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>250 мг каждые 24 часа</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг каждые 24 часа</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> каждые 24 часа</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>гемодиализ</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг каждые 24 часа</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг каждые 24 часа</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг каждые 24 часа</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>500 мг каждые 24 часа</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Клиренс креатинина определяется по формуле:</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Мужчины: </span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Женщины:</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>При гемодиализе за 3 часа из организма удаляется приблизительно 68 % от введенной дозы препарата. После каждого сеанса гемодиализа необходимо вводить повторную дозу, </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>аналогичную</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> первоначальной. При непрерывном амбулаторном перитонеальном диализе препарат можно применять в нормальных рекомендованных дозах в зависимости от тяжести инфекции, с интервалом между введениями разовой дозы 48 часов.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>При </span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>нарушении функции почек у детей рекомендуется снижение дозы или удлинение интервала между введениями, как указано в таблице 2</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>Расчет показателей клиренса креатинина у детей:</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU;mso-bidi-font-weight: bold;mso-bidi-font-style:italic' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU;mso-bidi-font-weight: bold;mso-bidi-font-style:italic'>или</span></p> <p><i land='' style=''>ведение препарата.</i><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'> </span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Цебопим ввод</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ить</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> внутривенно или глубоко внутримышечно в большую мышечную массу (например, в верхний наружный квадрант ягодичной мышцы).</span></p> <p><i land='' style=''>нутривенное введение.</i><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'> Данный путь введения </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>преимущественно применяется</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> пациент</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ам</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> с тяжёлыми, угрожающими жизни инфекциями.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>При</span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'> внутривенно</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>м </span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>способе введения Цебопим раствор</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>ить</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'> в 5 или 10 мл стерильной воды для инъекций, 5</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% раствор</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>е</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> глюкозы или 0,9</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% раствор</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>е</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> натрия хлорида, как указано в таблице 3. Готовый раствор ввод</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>ить</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>струйно </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>медленно в течение 3-5 мин</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ут</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> или </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>капельно </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>через систему для внутривенного введения.</span></p> <p><i land='' style=''>нутримышечное введение</i><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>. </span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>Цебопим раствор</span><span lang='UK' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>ить</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'> в стерильной воде для инъекций, 0,9</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% растворе натрия хлорида, 5</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% растворе </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>глюк</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>озы для инъекций, бактериостатической воде для инъекций с парабеном или бензиловым спиртом, 0,5</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% или 1</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% растворе лидокаина гидрохлорида в концентрациях, указанных в таблице 3.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>При применении лидокаина в качестве растворителя перед введением следует сделать </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>кожную </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>пробу на его переносимость.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Как и другие лекарственные средства, применяемые парентерально, готовые растворы препарата перед введением необходимо проверять на отсутствие механических включений.</span></p> <p><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>Таблица 3.</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Объем раствора для разведения (мл)</span><span style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Приблизительный объем полученного раствора (мл)</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Приблизительная концентрация цефепима (мг/мл)</span><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>нутривенное введение </span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>500 мг/флакон</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>5</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>5,</span><span lang='EN-US' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: RU'>7</span></p> <p><span lang='EN-US' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-US;mso-fareast-language:RU'>9</span><span lang='UK' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>0</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>1 г/флакон</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>10</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>11,</span><span lang='EN-US' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: RU'>4</span></p> <p><span lang='EN-US' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-US;mso-fareast-language:RU'>9</span><span lang='UK' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>0</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>2 г/флакон</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>10</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>12,</span><span lang='EN-US' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: RU'>8</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>160</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>нутримышечное введение</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>500 мг/флакон</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>1,</span><span lang='EN-US' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: RU'>5</span></p> <p><span lang='EN-US' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-US;mso-fareast-language:RU'>2</span><span lang='UK' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>,</span><span lang='EN-US' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'>2</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>2</span><span lang='EN-US' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: RU'>3</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>0</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>1 г/флакон</span></p> <p><span lang='EN-US' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-US;mso-fareast-language:RU'>3</span><span lang='UK' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>,</span><span lang='EN-US' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'>0</span></p> <p><span lang='EN-US' style='font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-US;mso-fareast-language:RU'>4</span><span lang='UK' style='font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>,</span><span lang='EN-US' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'>4</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>2</span><span lang='EN-US' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: RU'>3</span><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>0</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Препарат применя</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>ть</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> детям в возрасте от 1 месяца. </span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU;mso-bidi-font-weight:bold'>При применении лидокаина в качестве растворителя следует учесть информацию по безопасности лидокаина.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Передозировка. </b><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Симптомы: </i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>в случае значительного превышения рекомендованных доз, особенно у </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>пациентов</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> с нарушенной функцией почек, усиливаются проявления побочного действия. Симптомы передозировки включают энцефалопатию, сопровождающ</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>ую</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>ся галлюцинациями, нарушением сознания, ступором, комой, миоклонией, эпилептоформны</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>ми</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'> приступами, нейромышечной возбудимостью.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Лечение.</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> Следует прекратить введение препарата, провести симптоматическую терапию. Применение гемодиализа ускоряет выведение цефепима из организма; перитонеальный диализ малоэффективен. Тяжелые аллергические реакции немедленного типа требуют применения адреналина и других форм интенсивной терапии.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Побочные </b><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>реакции</b><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>. </b></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Побочные реакции наблюдаются редко.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Иммунная система:</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> реакции гиперчувствительности, включая анафилакси</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>ю</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>, анафилактический шок, ангионевротический отек.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Кожа и подкожная клетчатка:</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> кожные высыпания, зуд, крапивница.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Пищеварительная система:</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> тошнота, рвота, кандидоз ротовой полости, диарея, колит, запор, боль в животе, диспепсия, изменение ощущения вкуса.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Гепатобилиарная система: </i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>гепатит, холестатическая желтуха.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Нервная система:</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> головокружение, головная боль, беспокойство, бессонница, парестезии, спутанность/потеря сознания, судороги/эпилептоформные припадки, миоклония, энцефалопатия, галлюцинации, ступор, кома.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Общие нарушения и изменения в месте введения:</i><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> повышение температуры тела, потливость, боль в груди/спине, астения, изменения в месте введения, включая воспаление, флебит, боль.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Инфекции:</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> кандидоз, вагинит, генитальный зуд, псевдомембранозный колит, другие суперинфекции.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Дыхательная система:</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> нарушения дыхания, кашель, боль в горле, одышка.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Сердечно-сосудистая система:</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> тахикардия, вазодилатация, боль в области сердца.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Мочевыделительн</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>ая</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'> систем</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>а</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>:</i><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'> почечная недостаточность.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Кровь и лимфатическая систем</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>а</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>: </i><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>анемия, эозинофилия, транзиторная лейкопения, нейтропения, агранулоцитоз, тромбоцитопения.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Лабораторные показатели:</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> повышение уровня аланинаминотрансферазы, аспарататаминотрансферазы, щелочной фосфатазы, общего билирубина</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'> в плазме крови</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>, увеличение протромбинового времени или парциального тромболастинового времени (ПТТ) и положительный результат теста Кумбса без гемолиза, временное увеличение азота мочевины крови и/или креатинина сыворотки крови, ложноположительные реакции на глюкозу в мочи.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Кроме вышеупомянутых побочных реакций возможные побочные реакции, характерные для антибиотиков группы цефалоспоринов</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>:</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'> синдром Стивенса-Джонсона, мультиформная эритема, токсический эпидермальный некролиз, токсическая нефропатия, апластическая анемия, гемолитическая анемия, кровотечения, нарушение функции печени, холестаз, панцитопения.</span><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'></span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Срок годности. </b><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'>3 года.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Условия хранения.</b><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> оригинальной упаковке </span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> при температуре не вы</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ш</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>е 30 °С. Хранить в недоступном для детей месте.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'></span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Г</span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'>отовы</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>й</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> раствор препарата стабил</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>ен</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> в течение 24 часов при комнатной температуре или 7 дней при хранении в холодильнике (2-8 °С). С микробиологической точки зрения данное лекарственное средство следует применять немедленно. Если его не используют немедленно, то ответственность за время и условия хранения в процессе применения возлагается на потребителя.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Несовместимость. </b><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'>о избежание возможного лекарственного взаимодействия</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>,</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> Цебопим (как большинство других бета-лактамных антибиотиков) не </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>следует</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> вводить в одном шприце с метронидазолом, ванкомицином, гентамицином, тобрамицина сульфатом и нетилмицина сульфатом. случае назначения препарата Цебопим с вышеперечисленными препаратами следует вводить каждый антибиотик отдельно.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Не смешивать в одной емкости с другими препаратами. Применять растворители, перечисленные в разделе «Способ применения и дозы».</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'></span></p>

Умови зберігання: Умови зберігання Цебопім порошок для ін'єкцій 1 г 1 флакон

<p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'></b><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> оригінальній упаковці при температурі не вище </span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>30 оС.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> Зберігати у недоступному для дітей місці.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Готовий розчин препарату стабільний впродовж 24 годин при кімнатній температурі або 7 днів при зберіганні в холодильнику (2-8 °С).</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> З мікробіологічної точки зору даний лікарський засіб слід застосовувати негайно. Якщо його не використовують негайно, то відповідальність за час і умови зберігання в процесі застосування покладається на споживача.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Несумісність. </b><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>Щоб уникнути можливої лікарської взаємодії, Цебопім (як більшість інших бета-лактамних антибіотиків) не слід вводити в одному шприці з метронідазолом, ванкоміцином, гентаміцином, тобраміцину сульфатом та нетилміцину сульфатом. У випадку призначення препарату Цебопім з вищеперерахованими препаратами слід вводити кожний антибіотик окремо.</span></p>

Діюча речовина: Діюча речовина Цебопім порошок для ін'єкцій 1 г 1 флакон

<p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>діюча речовина:</i><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";letter-spacing: -.2pt;mso-ansi-language:UK;mso-fareast-language:RU'> цефепім у вигляді цефепіму дигідрохлориду моногідрату (</span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'>стерильного у перерахуванні на 100 % безводний цефепім</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";letter-spacing:-.2pt;mso-ansi-language:UK;mso-fareast-language: RU'>) – 500 мг,</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";letter-spacing:-.2pt;mso-fareast-language: RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";letter-spacing:-.2pt;mso-fareast-language: RU'> 1 г, 2 г;</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>допоміжна речовина: </i><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; letter-spacing:-.2pt;mso-ansi-language:UK;mso-fareast-language:RU'>L-аргінін.</span></p>

Водіння авто: Водіння авто Цебопім порошок для ін'єкцій 1 г 1 флакон

<p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Не вивчалася. У разі виникнення запаморочення, галюцинацій, сплутаності свідомості або інших побічних ефектів з боку нервової системи, що можуть впливати на швидкість реакції, слід утримуватися від керування автомобілем або іншими механізмами.</span></p>

Інші лікарські форми: Інші лікарські форми Цебопім порошок для ін'єкцій 1 г 1 флакон

<p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Розчин цефепіму сумісний із наступними парентеральними розчинами: 0,9 % розчином натрію хлориду, 5 % або 10 % розчинами глюкози, 6 М розчином натрію лактату для ін’єкцій, розчином Рінгера лактату з 5 % розчином декстрози для ін’єкцій.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>З огляду на потенційну нефротоксичність та ототоксичність аміноглікозидних антибіотиків, високі дози даних препаратів застосовують одночасно із цефепімом під контролем функції нирок. </span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Застосування цефалоспоринів з діуретиками (наприклад, фуросемід) призводить до підвищення нефротоксичності перших.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Щоб уникнути можливої лікарської взаємодії з іншими препаратами, розчин цефепіму (як і більшість інших бета-лактамних антибіотиків) не вводять одночасно з розчинами метронідазолу, ванкоміцину, гентаміцину, тобраміцину сульфату і нетилміцину сульфату. У разі призначення препарату Цебопім із зазначеними препаратами вводять кожен антибіотик окремо.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Супутнє лікування бактеріостатичними антибіотиками може впливати на дію бета-лактамних антибіотиків.</span></p> <p><i land='' style=''>плив на результати лабораторних тестів.</i></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Застосування цефепіму може призвести до хибнопозитивної реакції на глюкозу в сечі у разі використання реактиву Бенедикта. Рекомендується використовувати тести на глюкозу, засновані на ферментній реакції окислення глюкози.</span></p>

Фармакологічні властивості: Фармакологічні властивості Цебопім порошок для ін'єкцій 1 г 1 флакон

<p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Фармакодинаміка. </i></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Цефепім чинить дію шляхом пригнічення синтезу ферментів стінки бактерії. Препарат має широкий спектр дії щодо грампозитивних та грамнегативних бактерій, високу стійкість до гідролізу більшістю бета-лактамаз, має малу спорідненість відносно бета-лактамаз, що кодуються хромосомними генами, швидко проникає у грамнегативні бактеріальні клітини.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Цефепім активний відносно наступних мікроорганізмів:</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>грампозитивні аероби:</i><b land='' style=''> </b></p> <p><i land='' style=''>Staphylococcus aureus</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> (включаючи штами, що продукують бета-лактамазу); Staphylococcus epidermidis (включаючи штами, що продукують бета-лактамазу); інші штами стафілококів, включаючи S. hominis, S. saprophyticus; Streptococcus pyogenes (стрептококи групи А); Streptococcus agalactiae (стрептококи групи ); Streptococcus pneumoniae (включаючи штами із середньою стійкістю до пеніциліну – МПК від 0,1 до 1 мкг/мл); інші бета-гемолітичні стрептококи (групи C, G, F), S. bovis (група D), стрептококи групи Viridans.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Більшість штамів ентерококів, наприклад, Enterococcus faecalis, та стафілококи, резистентні до метициліну, резистентні до більшості цефалоспоринових антибіотиків, включаючи цефепім; </span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>грамнегативні аероби:</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> </i></p> <p><i land='' style=''>Pseudomonas</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> sрp</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>., включаючи P. aeruginosa, P. putida, P. stutzeri; Escherichia coli, Klebsiella sрp., включаючи K. pneumoniae, K. oxytoca, K. o</span><i land='' style=''>z</i><i land='' style=''>aenae; Enterobacter </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>sрp.,</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> включаючи E. cloacae, E. aerogenes, E. sakazakii; Proteus sрp., включаючи P. mirabilis, P. vulgaris; Acinetobacter calcoaceticus (subsp. anitratus, lwoffi); Aeromonas hydrophila; Capnocytophaga sрp.; Citrobacter sрp., включаючи C. diversus, C. freundii; Campylobacter jejuni; </span><i land='' style=''>G</i><i land='' style=''>ardnerella vaginalis; Haemophilus ducreyi; Haemophilus influenzae</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU;mso-bidi-font-style: italic'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>(включаючи штами, що продукують бета-лактамазу); Haemophilus parainfluenzae; Hafnia alvei; Legionella sрp.; Morganella morganii; Moraxella ca</span><i land='' style=''>t</i><i land='' style=''>arrhalis </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>(Branhamella catarrhalis)</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU;mso-bidi-font-style: italic'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>(включаючи штами, що продукують бета-лактамазу); Neisseria gonorrhoeae (включаючи штами, що продукують бета-лактамазу); Neisseria meningitidis; Providencia sрp. (включаючи P. retigeri, P. stuartii); Salmonella sрp.; Serratia (включаючи S. marcescens, S. liquefaciens); Shigella sрp.; Yersinia enterocolitica. </span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Цефепім неактивний відносно деяких штамів Xanthаmonas maltophilia (Pseudomonas maltophilia);</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>анаероби:</i><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'> </span></p> <p><i land='' style=''>Bacteroides sрp</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU;mso-bidi-font-style: italic'>.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>, включаючи B. melaninogenicus та інші мікроорганізми ротової порожнини, що належать до Bacteroides; Clostridium perfringens; Fusobacterium sрp.; Mobiluncus sрp.; Peptostreptococcus sрp.; Veillonella sрp. (цефепім неактивний щодо Bacteroides fragilis і Clostridium difficile). </span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Фармакокінетика. </i></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Період напіввиведення препарату – близько 2 годин. У здорових людей кумуляції препарату в організмі не спостерігалось.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Метаболізується цефепім у N-метилпіролідин, що швидко перетворюється в оксид N-метилпіролідину. Загальний кліренс становить 120 мл/хв. Препарат в основному виділяється нирками (середній нирковий кліренс становить 110 мл/хв). У сечі виявляється приблизно 85 % дози, яку ввели, у вигляді незміненого цефепіму, 1 % N-метилпіролідину, близько 6,8 % оксиду </span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>N-метилпіролідину та близько 2,5 % епімеру цефепіму. Зв’язування цефепіму з білками плазми крові не залежить від концентрації препарату в сироватці крові та становить менше ніж 19 %.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Цефепім добре розподіляється в організмі та досягає терапевтичної концентрації у сечі, жовчі, перитонеальній рідині, слизовому секреті бронхів, мокротинні, простаті, апендиксі та жовчному міхурі. </span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Концентрації цефепіму в плазмі крові у дорослих здорових чоловіків після одноразового внутрішньовенного/внутрішньом’язового введення наведені в таблиці нижче.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Середні концентрації цефепіму в плазмі крові (мкг/мл)</i></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>Доза цефепіму</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>0,5 години</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>1 година</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>2 години</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>4 години</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>8 годин</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>12 годин</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>нутрішньовенно</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>500 мг</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>38,2</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>21,6</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>11,6</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>5,0</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>1,4</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>0,2</span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>78,7</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>44,5</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>24,3</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>10,5</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>2,4</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>0,6</span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>163,1</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>85,8</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>44,8</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>19,2</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>3,9</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>1,1</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>нутрішньом’язово</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>500 мг</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>8,2</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>12,5</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>12,0</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>6,9</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>1,9</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>0,7</span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>14,8</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>25,9</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>26,3</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>16,0</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>4,5</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>1,4</span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>36,1</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>49,9</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>51,3</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>31,5</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>8,7</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>2,3</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>У пацієнтів із порушеннями функції нирок період напіввиведення цефепіму збільшується. У пацієнтів із тяжкими порушеннями функції нирок, що перебувають на діалізі, період напіввиведення становить 13 годин для гемодіалізу та 19 годин – для перитонеального діалізу.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Фармакокінетика цефепіму при порушеній функції печінки або муковісцидозі не змінюється. Для таких пацієнтів не потрібна корекція дози.</span></p>

Адреса: Адреса Цебопім порошок для ін'єкцій 1 г 1 флакон

<p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Місцезнаходження</b><b land='' style=''> виробника та адреса місця провадження його діяльності</b><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>. </b><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>Україна, 03134, м. Київ, вул. Миру, 17.</span></p> <p><b land='' style=''>ИНСТРУКЦИЯ</b></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>для медицинского применения лекарственного средства</b><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'></span></p> <p><b land='' style=''>ЦЕБОПИМ</b></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>(</b><b style='mso-bidi-font-weight: normal' style='mso-bidi-font-weight: normal'>CEBOPIM</b><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>)</b><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'></span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Состав:</b></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>действующее вещество:</i><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";letter-spacing:-.2pt;mso-fareast-language: RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";letter-spacing:-.2pt;mso-fareast-language: RU'> цефепим в виде цефепима дигидрохлорида моногидрата</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";letter-spacing:-.2pt;mso-ansi-language:UK;mso-fareast-language: RU'> (стерильного в пересчете на 100 % безводн</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; letter-spacing:-.2pt;mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; letter-spacing:-.2pt;mso-fareast-language:RU'>ый цефепим) </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";letter-spacing:-.2pt;mso-ansi-language:UK;mso-fareast-language: RU'>– </span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";letter-spacing:-.2pt;mso-fareast-language: RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";letter-spacing:-.2pt;mso-fareast-language: RU'>500</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";letter-spacing:-.2pt;mso-ansi-language: UK;mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";letter-spacing:-.2pt;mso-ansi-language: UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";letter-spacing: -.2pt;mso-fareast-language:RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";letter-spacing: -.2pt;mso-fareast-language:RU'>мг, 1 г, 2 г;</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>вспомогательное вещество:</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";letter-spacing:-.2pt;mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";letter-spacing:-.2pt;mso-fareast-language:RU'> </span><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";letter-spacing:-.2pt;mso-ansi-language:EN-US;mso-fareast-language: RU'>L</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";letter-spacing:-.2pt;mso-fareast-language: RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";letter-spacing:-.2pt;mso-fareast-language: RU'>-аргинин.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Лекарственная форма. </b><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>Порошок для раствора для инъекций.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Основные физико-химические свойства:</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> порошок от белого до светло-желтого цвета.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Фармакотерапевтич</b><b style='mso-bidi-font-weight: normal' style='mso-bidi-font-weight: normal'>еская</b><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'> группа.</b><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> Антибактериальные средства для системного применения. Прочие бета-лактамные антибиотики. Цефалоспорины IV поколения. Код </span><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>AT</b><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Х</b><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'>J</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>01</span><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'>D</span><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> </span><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'>E</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>01.</span></p> <p><b style='mso-bidi-font-weight:normal' style='mso-bidi-font-weight:normal'>Фармакологические свойства.</b></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Фармакодинамика. </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'></i></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Цефепим оказывает действие путем угнетения синтеза ферментов стенки бактерии. Препарат имеет широкий спектр действия относительно грамположительных и грамотрицательных бактерий, высоко устойчив к гидролизу большинством бета-лактамаз, обладает малым сродством в отношении бета-лактамаз, кодируемых хромосомными генами, быстро проникает в грамотрицательные бактериальные клетки.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Це</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>фе</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>пим активен в отношении следующих микроорганизмов:</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>г</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>рамположительные аэробы:</i><b land='' style=''> </b></p> <p><i land='' style=''>Staphylococcus</i><i land='' style=''> </i><i land='' style=''>aureus</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> (включая штаммы, продуцирующие бета-лактамазу); </span><i land='' style=''>Staphylococcus</i><i land='' style=''> </i><i land='' style=''>epidermidis</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU;mso-bidi-font-style:italic' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU;mso-bidi-font-style:italic'> (</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>включая штаммы, продуцирующие бета-лактамазу); другие штаммы стафилококков, включая </span><i land='' style=''>S</i><i land='' style=''>. </i><i land='' style=''>hominis</i><i land='' style=''>, </i><i land='' style=''>S</i><i land='' style=''>. </i><i land='' style=''>saprophyticus</i><i land='' style=''>; </i><i land='' style=''>Streptococcus</i><i land='' style=''> </i><i land='' style=''>pyogenes</i><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU;mso-bidi-font-style:italic'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>(стрептококки группы А); </span><i land='' style=''>Streptococcus</i><i land='' style=''> </i><i land='' style=''>agalactiae</i><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU;mso-bidi-font-style:italic'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>(стрептококки группы ); </span><i land='' style=''>Streptococcus</i><i land='' style=''> </i><i land='' style=''>pneumoniae</i><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU;mso-bidi-font-style:italic'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>(включая штаммы со средней устойчивостью к пенициллину – МПК от 0,1 до 1 мкг/мл); другие бета-гемолитические стрептококки (группы </span><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'>C</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>, </span><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'>G</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>, </span><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'>F</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>),</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><i land='' style=''>S</i><i land='' style=''>. </i><i land='' style=''>bovis</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> (группа </span><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'>D</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>), стрептококки группы </span><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Viridans</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Большинство штаммов энтерококков, например, Enterococcus faecalis, и стафилококки, резистентные к метициллину, резистентны к большинству цефалоспориновых антибиотиков, включая цефепим</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>;</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>грамотрицательные аэробы:</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> </i></p> <p><i land='' style=''>Pseudomonas</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>р</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>p</i><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>.,</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>включая </span><i land='' style=''>P</i><i land='' style=''>. </i><i land='' style=''>aeruginosa</i><i land='' style=''>, </i><i land='' style=''>P</i><i land='' style=''>. </i><i land='' style=''>putida</i><i land='' style=''>, </i><i land='' style=''>P</i><i land='' style=''>. </i><i land='' style=''>stutzeri</i><i land='' style=''>; </i><i land='' style=''>Escherichia</i><i land='' style=''> </i><i land='' style=''>coli</i><i land='' style=''>, </i><i land='' style=''>Klebsiella</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>р</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>p</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>.,</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> включая </span><i land='' style=''>K</i><i land='' style=''>. </i><i land='' style=''>pneumoniae</i><i land='' style=''>, </i><i land='' style=''>K</i><i land='' style=''>. </i><i land='' style=''>oxytoca</i><i land='' style=''>, </i><i land='' style=''>K</i><i land='' style=''>. </i><i land='' style=''>o</i><i land='' style=''>z</i><i land='' style=''>aenae</i><i land='' style=''>; </i><i land='' style=''>Enterobacter</i><i land='' style=''> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>р</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>p</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>., включая </i><i land='' style=''>E</i><i land='' style=''>. </i><i land='' style=''>cloacae</i><i land='' style=''>, </i><i land='' style=''>E</i><i land='' style=''>. </i><i land='' style=''>aerogenes</i><i land='' style=''>, </i><i land='' style=''>E</i><i land='' style=''>. </i><i land='' style=''>sakazakii</i><i land='' style=''>; </i><i land='' style=''>Proteus</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>р</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>p</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>., </i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>включая </span><i land='' style=''>P</i><i land='' style=''>. </i><i land='' style=''>mirabilis</i><i land='' style=''>, </i><i land='' style=''>P</i><i land='' style=''>. </i><i land='' style=''>vulgaris</i><i land='' style=''>; </i><i land='' style=''>Acinetobacter</i><i land='' style=''> </i><i land='' style=''>calcoaceticus</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> (</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>subsp</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>. </i><i land='' style=''>anitratus</i><i land='' style=''>, </i><i land='' style=''>l</i><i land='' style=''>woffi</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>); </i><i land='' style=''>Aeromonas</i><i land='' style=''> </i><i land='' style=''>hydrophila</i><i land='' style=''>; </i><i land='' style=''>Capnocytophaga</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>р</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>p</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>.; </i><i land='' style=''>Citrobacter</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>р</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>p</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>., </i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>включая </span><i land='' style=''>C</i><i land='' style=''>. </i><i land='' style=''>diversus</i><i land='' style=''>, </i><i land='' style=''>C</i><i land='' style=''>. </i><i land='' style=''>freundii</i><i land='' style=''>; </i><i land='' style=''>Campylobacter</i><i land='' style=''> </i><i land='' style=''>jejuni</i><i land='' style=''>; </i><i land='' style=''>G</i><i land='' style=''>ardnerella</i><i land='' style=''> </i><i land='' style=''>vaginalis</i><i land='' style=''>; </i><i land='' style=''>Haemophilus</i><i land='' style=''> </i><i land='' style=''>ducreyi</i><i land='' style=''>; </i><i land='' style=''>Haemophilus</i><i land='' style=''> </i><i land='' style=''>influenzae</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU;mso-bidi-font-style: italic' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU;mso-bidi-font-style: italic'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>(включая штаммы, продуцирующие бета-лактамазу); </span><i land='' style=''>Haemophilus</i><i land='' style=''> </i><i land='' style=''>parainfluenzae</i><i land='' style=''>; </i><i land='' style=''>Hafnia</i><i land='' style=''> </i><i land='' style=''>alvei</i><i land='' style=''>; </i><i land='' style=''>Legionella</i><i land='' style=''> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>р</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>p</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>.; </i><i land='' style=''>Morganella</i><i land='' style=''> </i><i land='' style=''>morganii</i><i land='' style=''>; </i><i land='' style=''>Moraxella</i><i land='' style=''> </i><i land='' style=''>ca</i><i land='' style=''>t</i><i land='' style=''>arrhalis</i><i land='' style=''> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>(</i><i land='' style=''>Branhamella</i><i land='' style=''> </i><i land='' style=''>catarrhalis</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>)</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU;mso-bidi-font-style: italic'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>(включая штаммы, продуцирующие бета-лактамазу); </span><i land='' style=''>Neisseria</i><i land='' style=''> </i><i land='' style=''>gonorrhoeae</i><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU;mso-bidi-font-style: italic' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU;mso-bidi-font-style: italic'> </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>(включая штаммы, продуцирующие бета-лактамазу); </span><i land='' style=''>Neisseria</i><i land='' style=''> </i><i land='' style=''>meningitidis</i><i land='' style=''>; </i><i land='' style=''>Providencia</i><i land='' style=''> </i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>s</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>р</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>p</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>.</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='EN-US' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:RU'>(</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>включая</span><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'> P. rettgeri, </span><i land='' style=''></i></p> <p><i land='' style=''>P.</i><i land='' style=''> </i><i land='' style=''>stuartii</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>);</i><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU;mso-bidi-font-style: italic'> Salmonella </span><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>р</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>p.; Serratia</i><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU;mso-bidi-font-style: italic'> </span><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: RU'>(</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>включая</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'> S. marcescens, S. liquefaciens); Shigella s</span><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>р</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>p.; Yersinia enterocolitica. </i></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Цефепим</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>неактивен</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>в</span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>отношении</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>некоторых</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>штаммов</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'> Xanth</span><i land='' style=''>а</i><i land='' style=''>monas maltophilia </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>(Pseudomonas maltophilia)</i><i land='' style=''>;</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>анаэробы:</i><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'> </span></p> <p><i land='' style=''>Bacteroides</i><i land='' style=''> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>р</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>p</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>., включая </span><i land='' style=''>B</i><i land='' style=''>. </i><i land='' style=''>melaninogenicus</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> и другие микроорганизмы ротовой полости, относящиеся к </span><i land='' style=''>Bacteroides</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>; </i><i land='' style=''>Clostridium</i><i land='' style=''> </i><i land='' style=''>perfringens</i><i land='' style=''>; </i><i land='' style=''>Fusobacterium</i><i land='' style=''> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>р</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>p</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>.; </i><i land='' style=''>Mobiluncus</i><i land='' style=''> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>р</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>p</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>.; </i><i land='' style=''>Peptostreptococcus</i><i land='' style=''> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>р</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>p</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>.; </i><i land='' style=''>Veillonella</i><i land='' style=''> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>s</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>р</i><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>p</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>.</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> (цефепим неактивен в отношении </span><i land='' style=''>Bacteroides</i><i land='' style=''> </i><i land='' style=''>fragilis</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> и </span><i land='' style=''>Clostridium</i><i land='' style=''> </i><i land='' style=''>difficile</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>). </span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Фармакокинетика. </i></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Период полувыведения препарата – около 2 часов. У здоровых людей кумуляции препарата в организме не отмечалось.</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Метаболизируется </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'> </span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>цефепим </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>в </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span lang='EN-US' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:RU'>N</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>-метилпиролидин, </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>который </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>быстро</span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'> </span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>превращается </span><span lang='UK' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>в</span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'> </span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>оксид </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span lang='EN-US' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:RU'>N</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>-метилпиролидина. Общий клиренс составляет 120 мл/мин. Препарат в основном выделяется почками (средний почечный клиренс составляет 110 мл/мин). моче обнаруживается приблизительно 85</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% введенной дозы в виде неизмененного цефепима, 1 % </span><span lang='EN-US' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:RU'>N</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>-метилпиролидина, около 6,8</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% оксида </span><span lang='EN-US' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU'>N</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>-метилпиролидина и около 2,5</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>% эпимера цефепима. Связывание цефепима с белками плазмы </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>крови </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>не зависит от концентрации препарата в сыворотке крови и составляет менее чем 19</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>%.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Цефепим хорошо распределяется в организме и достигает терапевтической концентрации в моче, желчи, перитонеальной жидкости, слизистом секрете бронхов, мокроте, простате, аппендиксе и желчном пузыре. </span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Концентрации цефепима в плазме крови у взрослых здоровых мужчин после однократного внутривенного/внутримышечного введения приведены в таблице </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>ниже</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Средние концентрации цефепима в плазме </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>крови </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>(мкг/мл)</i></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Доза цефепима</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>0,5 </span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>часа</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>1 час</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>2 час</span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>4 </span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>часа</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>8 </span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>часов</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>12 </span><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>часов</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>нутривенно</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>500 мг</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>38,2</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>21,6</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>11,6</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>5,0</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>1,4</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>0,2</span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>78,7</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>44,5</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>24,3</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>10,5</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>2,4</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>0,6</span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>163,1</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>85,8</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>44,8</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>19,2</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>3,9</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>1,1</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>нутримышечно</span></p> <p><span style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>500 мг</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>8,2</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>12,5</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>12,0</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>6,9</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>1,9</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>0,7</span></p> <p><metricconverter productid='1 ГЈ' style=''>1 г</metricconverter><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>14,8</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>25,9</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>26,3</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>16,0</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>4,5</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>1,4</span></p> <p><metricconverter productid='2 ГЈ' style=''>2 г</metricconverter><span style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>36,1</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>49,9</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>51,3</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>31,5</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>8,7</span></p> <p><span lang='UK' style='font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>2,3</span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>У пациентов с </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>нарушениями функции почек</span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'> период полувыведения цефепима увеличивается. У пациентов с тяжёлыми нарушениями функции почек, находящихся на диализе, период полувыведения составляет 13 часов для гемодиализа и 19 часов – для перитонеального диализа. </span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Фармакокинетика цефепима при нарушенной функции печени или муковисцидозе не изменена. Для таких пациентов не требуется коррекция дозы. </span></p>

Особливості: Особливості Цебопім порошок для ін'єкцій 1 г 1 флакон

<p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Гіперчутливість</i></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Перед застосуванням препарату необхідно з’ясувати, чи відзначалися раніше у пацієнта реакції гіперчутливості негайного типу на цефепім, цефалоспорини, пеніциліни або інші бета-лактамні антибіотики. </span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Цефепім слід застосовувати з обережністю пацієнтам з астмою або алергічним діатезом. Стан пацієнта необхідно ретельно контролювати під час першого введення. </span><span style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-fareast-language: RU'>Якщо виникає алергічна реакція, лікування слід негайно припинити.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Антибіотики </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>слід</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> призначати з обережністю всім </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>пацієнтам</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> із будь-якими формами алергії, особливо на лікарські препарати. При появі алергічної реакції застосування препарату </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>слід</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> припинити. Серйозні реакції гіперчутливості негайного типу можуть вимагати застосування адреналіну та інших форм терапії.</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'> </span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>У пацієнтів із високим ризиком тяжких інфекцій (наприклад, у пацієнтів, які мали в анамнезі трансплантацію кісткового мозку при зниженій його активності, що виникає на тлі злоякісної гематологічної патології з тяжкою прогресуючою нейтропею) монотерапія може бути недостатньою, тому показана комплексна антимікробна терапія.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Антибактеріальна активність цефепіму</i></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Малоймовірно, що призначення цефепіму при відсутності доведеної або підозрюваної бактеріальної інфекції або його профілактичне застосування буде корисним, але це може збільшити ризик появи бактерій, несприйнятливих до цього препарату. </span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'> </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Тривале застосування цефепіму (як і інших антибіотиків) може призводити до розвитку суперінфекції. Необхідно проводити повторну перевірку стану пацієнта. У разі розвитку суперінфекції необхідно розпочати адекватні заходи лікування.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Ниркова недостатність</i></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Пацієнтам з порушенням функції нирок (з кліренсом креатиніну < 50 мл/хв) дозу препарату слід відкоригувати, щоб компенсувати сповільнення швидкості ниркового виведення. Оскільки високі концентрації антибіотика у сироватці крові можуть мати місце при звичайних дозах у пацієнтів з нирковою недостатністю або іншими станами, що можуть погіршити функції нирок, при введені цефепіму таким пацієнтам підтримуюча доза повинна бути знижена. При визначенні наступної дози препарату слід враховувати ступінь порушення функції нирок, тяжкість інфекції і сприйнятливості до мікроорганізмів, які спричинили інфекцію,.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Під час постмаркетингового дослідження були зареєстровані наступні серйозні побічні реакції: оборотна енцефалопатія (порушення свідомості, включаючи сплутаність, галюцинації, ступор і кома), міоклонус, судоми (у т.ч. епілептичний статус) та/або ниркова недостатність. Більшість випадків спостерігалися у пацієнтів з нирковою недостатністю, які отримували дози цефепіму, що перевищували рекомендовані.</span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>У більшості випадків симптоми нефротоксичності були оборотні і зникали після припинення застосування цефепіму та/або після гемодіалізу.</span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Clostridium</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>difficile</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> асоційована діарея</i></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>Повідомлялося про антибіотико-асоційовану діарею та антибіотико-асоційований коліт, включаючи псевдомембранозний коліт та діарею, повКјязану з </span><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Clostridium</i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'> </i><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>difficile</i><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>, у звКјязку з застосуванням майже всіх антибіотиків, включаючи цефепім, що може варіювати від легкої діареї до коліту з летальним наслідком. </span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>Тому важливо враховувати цей діагноз у пацієнтів, у яких розвивається серйозна діарея під час або після застосування цефепіму. Якщо підозрюється або підтверджується </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>антибіотико-асоційована діарея або антибіотико-асоційований коліт</span><span style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>, слід припинити лікування антибактеріальними засобами, </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>включаючи</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> цефепім, і негайно розпочати адекватні терапевтичні заходи. Препарати, що пригнічують перистальтику, в даній ситуації протипоказані.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><i style='mso-bidi-font-style:normal' style='mso-bidi-font-style:normal'>Пацієнти літнього віку</i></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>ідомо, що цефепім значною мірою виділяється нирками і ризик токсичних реакцій на цей препарат може бути вищим у пацієнтів з нирковою недостатністю. Оскільки літні пацієнти більш схильні до зниження функції нирок, слід обережно підходити до вибору дози, а функцію нирок слід контролювати. </span></p> <p><i style='mso-bidi-font-style: normal' style='mso-bidi-font-style: normal'>Серологічне тестування</i></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>Цефалоспорини схильні абсорбуватися на поверхні еритроцитів і вступати в реакцію з антитілами, спрямованими проти препаратів, результатом </span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>чого</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> є позитивний тест Кумбса. У пацієнтів, які </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:UK;mso-fareast-language: RU'>застосовували</span><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'> цефепім 2 рази на добу, описано позитивний тест Кумбса </span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'>при</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> відсутності ознак гемолізу.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'>При проведенні аналізу сечі на глюкозурію можливий хибно</span><span lang='UK' style='font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:RU'>-</span><span style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-fareast-language:RU'>позитивний результат. Із причини визначення глюкози в сечі слід проводити глюкозооксидазними методами</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'> у</span><span style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-fareast-language:RU'> період лікування препаратом.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU' style='font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU'>Необхідно здійснювати контроль протромбінового часу.</span><span lang='UK' style='font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:UK;mso-fareast-language:RU'></span></p> <p><span lang='UK' style='font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: UK;mso-fareast-language:RU'>При застосуванні лідокаїну як розчинника слід врахувати інформацію з безпеки лідокаїну.</span></p> <p><span lang='UK' style='font-size: 12.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:UK;mso-fareast-language:UK'>Було доведено, що L-аргінін змінює метаболізм глюкози та одночасно збільшує рівні калію у сироватці крові при застосуванні доз, які у 33 рази перевищують максимальну рекомендовану дозу цефепіму. Ефекти при більш низьких дозах на даний момент невідомі.</span></p>